Ended a six-year FA Cup drought ruthlessly, crushing Wigan 4-0 within 27 devastating first-half minutes.
Noni Madueke and Gabriel Martinelli struck early before Jack Hunt’s own goal, and a Gabriel Jesus finish sealed humiliation for the third-tier side.
The Gunners are now back in the last 16 for the first time since lifting the trophy in 2020.
With a four-point Premier League lead, a League Cup final looming, and Champions League ambitions alive, Arsenal’s quadruple dream gathers pace.
Elsewhere, Leeds survived a penalty shoot-out against Birmingham, Wolves edged Grimsby 1-0, and Fulham staged a comeback win at Stoke.
Sunderland also scraped past Oxford via a penalty.
Fourteen teams, including Chelsea, Manchester City, Liverpool, and Newcastle, now await the fifth-round draw as the FA Cup narrative intensifies.